Protein knowledgebaseProtein sets from fully sequenced genomesSequence clustersSupporting dataSelect one of the options below to target your search:Sequence archiveHelp pages, FAQs, UniProtKB manual, documents, news archive, etc.You are using a version of browser that may not display all the features of this website. Please consider upgrading .Q15759- MK11_HUMANUniProtQ15759 - MK11_HUMAN(max 400 entries)Your basket is currently empty.Select item(s) and click on "Add to basket" to create your own collection here (400 entries max)Mitogen-activated protein kinase 11MAPK11Homo sapiens (Human)Annotation score: 5 out of 5- Experimental evidence at protein leveli
Entry version 161 (26 Nov 2014)Sequence version 2 (20 Mar 2007) | FunctioniSerine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment."Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6.", ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION IN PHOSPHORYLATION OF ATF2; ELK1 AND MBP, ENZYME REGULATION. "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.", , ,
[] [] []Cited for: FUNCTION IN ACTIVATION OF RPS6KA5/MSK1. "Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors.", , Mol. Cell. Biol. 19:99)
[] [] []Cited for: FUNCTION IN PHOSPHORYLATION OF MEF2A AND MEF2C. "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.", , ,
[] [] []Cited for: FUNCTION AS MKNK2 KINASE. "Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression.", , , ,
[] [] []Cited for: INTERACTION WITH HDAC3, PHOSPHORYLATION, ENZYME REGULATION, FUNCTION IN ATF2 ACTIVATION. Catalytic activityiATP + a protein = ADP + a phosphoprotein.CofactoriEnzyme regulationiActivated by phosphorylation on threonine and tyrosine by MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6. MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 induced by environmental stress. HDAC3 interacts directly and selectively with MAPK11 to repress ATF2 transcriptional activity, and regulate TNF gene expression in LPS-stimulated cells. Inhibited by SB203580 and pyridinyl-imidazole related compounds."Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6.", ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION IN PHOSPHORYLATION OF ATF2; ELK1 AND MBP, ENZYME REGULATION. "Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.", , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ENZYME REGULATION. "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs.", , ,
[] [] []Cited for: INTERACTION WITH DUSP16, ENZYME REGULATION. "Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression.", , , ,
[] [] []Cited for: INTERACTION WITH HDAC3, PHOSPHORYLATION, ENZYME REGULATION, FUNCTION IN ATF2 ACTIVATION. SitesFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsBinding sitei1ATPBinding sitei1NilotinibActive sitei1Proton acceptorRegionsFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsNucleotide bindingi9ATPGO - Molecular functioniGO - Biological processiKeywords - Molecular functioni, , Keywords - Biological processi, , Keywords - Ligandi, Enzyme and pathway databases
BRENDAi 2681.
Reactomei p38MAPK events.
ERK/MAPK targets.
Oxidative Stress Induced Senescence.
Activation of PPARGC1A (PGC-1alpha) by phosphorylation.
Activation of the AP-1 family of transcription factors.
activated TAK1 mediates p38 MAPK activation.
CDO in myogenesis.
VEGFA-VEGFR2 Pathway.
KSRP destabilizes mRNA.
DSCAM interactions.
NOD1/2 Signaling Pathway.
SignaLinki Names & TaxonomyiProtein namesiRecommended name:Mitogen-activated protein kinase 11 (EC:)Short name: MAP kinase 11Short name: MAPK 11Alternative name(s):Mitogen-activated protein kinase p38 betaShort name: MAP kinase p38 betaShort name: p38bStress-activated protein kinase 2bShort name: SAPK2bp38-2Gene namesiName:Synonyms:PRKM11, SAPK2, SAPK2BOrganismiTaxonomic identifieri
[]Taxonomic lineagei &
Proteomesi: Chromosome 22Organism-specific databases
HGNCi MAPK11. Subcellular locationi .
GO - Cellular componentiKeywords - Cellular componenti, Pathology & BiotechiMutagenesisOrganism-specific databases
PharmGKBi PTM / ProcessingiMolecule processingFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsChaini364Mitogen-activated protein kinase 11PRO_Amino acid modificationsFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsModified residuei1P by MAP2K3, MAP2K4 and MAP2K6"Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression.", , , ,
[] [] []Cited for: INTERACTION WITH HDAC3, PHOSPHORYLATION, ENZYME REGULATION, FUNCTION IN ATF2 ACTIVATION. Modified residuei1P by MAP2K3, MAP2K4 and MAP2K6"Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression.", , , ,
[] [] []Cited for: INTERACTION WITH HDAC3, PHOSPHORYLATION, ENZYME REGULATION, FUNCTION IN ATF2 ACTIVATION. Modified residuei1P by ZAP70Post-translational modificationiDually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6, which activates the enzyme."Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression.", , , ,
[] [] []Cited for: INTERACTION WITH HDAC3, PHOSPHORYLATION, ENZYME REGULATION, FUNCTION IN ATF2 ACTIVATION. Keywords - PTMiProteomic databases
PRIDEi PTM databases
PhosphoSitei ExpressioniTissue specificityiHighest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.Gene expression databases
ExpressionAtlasi baseline and differential.
Genevestigatori Organism-specific databases
HPAi InteractioniSubunit structureiInteracts with HDAC3 and DUSP16."A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs.", , ,
[] [] []Cited for: INTERACTION WITH DUSP16, ENZYME REGULATION. "Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression.", , , ,
[] [] []Cited for: INTERACTION WITH HDAC3, PHOSPHORYLATION, ENZYME REGULATION, FUNCTION IN ATF2 ACTIVATION. "The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha.", , , , , , , , ,
[] [] []Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) IN COMPLEX WITH INHIBITOR. Binary interactionsiWithEntry#Exp.IntActNotesTP532ZNHIT12Protein-protein interaction databases
BioGridi 28 interactions.
IntActi 21 interactions.
STRINGi StructureiSecondary structure1364Legend: HelixTurnBeta strandFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsBeta strandi8Beta strandi5Beta strandi6Beta strandi3Turni4Beta strandi6Turni4Beta strandi7Helixi16Beta strandi5Helixi3Beta strandi5Beta strandi3Helixi7Helixi20Helixi3Beta strandi3Beta strandi3Helixi4Helixi4Helixi4Helixi16Helixi12Helixi6Turni3Helixi5Helixi4Turni3Helixi7Turni3Helixi3Helixi4Helixi3Turni3Helixi3Helixi4Helixi143D structure databases
Select the link destinations:PDBeiRCSB PDBiPDBji
EntryMethodResolution (&A)ChainPositionsPDBsumX-ray2.40A/B[]X-ray2.05A/B[]X-ray1.90A[]
ProteinModelPortali
SMRi Positions
MobiDBiMiscellaneous databases
EvolutionaryTracei Family & DomainsiDomains and RepeatsFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsDomaini285Protein kinaseRegionFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsRegioni5Inhibitor-bindingRegioni2Inhibitor-bindingMotifFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsMotifi3TXYDomainiThe TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.Sequence similaritiesiBelongs to the . . .Contains 1 .Phylogenomic databases
InParanoidi
PhylomeDBi
TreeFami Family and domain databases
InterProi Kinase-like_dom.
MAP_kinase_CS.
Prot_kinase_dom.
Protein_kinase_ATP_BS.
Ser/Thr_dual-sp_kinase.
Pfami Pkinase. 1 hit.
PRINTSi P38MAPKINASE.
SMARTi S_TKc. 1 hit.
SUPFAMi SSF56112. 1 hit.
PROSITEi MAPK. 1 hit.
PROTEIN_KINASE_ATP. 1 hit.
PROTEIN_KINASE_DOM. 1 hit.
[]Sequences (2)iSequence statusi: Complete.This entry describes 2 isoformsi produced by alternative splicing.
(identifier: Q15759-1)
[]This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
50MSGPRAGFYR QELNKTVWEV PQRLQGLRPV GSGAYGSVCS AYDARLRQKV
100AVKKLSRPFQ SLIHARRTYR ELRLLKHLKH ENVIGLLDVF TPATSIEDFS
150EVYLVTTLMG ADLNNIVKCQ ALSDEHVQFL VYQLLRGLKY IHSAGIIHRD
200LKPSNVAVNE DCELRILDFG LARQADEEMT GYVATRWYRA PEIMLNWMHY
250NQTVDIWSVG CIMAELLQGK ALFPGSDYID QLKRIMEVVG TPSPEVLAKI
300SSEHARTYIQ SLPPMPQKDL SSIFRGANPL AIDLLGRMLV LDSDQRVSAA
350EALAHAYFSQ YHDPEDEPEA EPYDESVEAK ERTLEEWKEL TYQEVLSFKP
360 PEPPKPPGSL EIEQ
36441,357March 20, 2007 - v2Checksum:i68DA4C7B7C721475BLASTProtParamCompute pI/MWProtScalePeptideMassPeptideCutter (identifier: Q15759-3)
[]The sequence of this isoform differs from the canonical sequence as follows:&&&&&: Missing.&&&&&: VDIWSVGCIM...HDPEDEPEAE&&&GAGGRPWGDE...GYLVRGLHHG&&&&&: Missing.Note: No experimental confirmation available.&21323,603Checksum:iED27A3BLASTProtParamCompute pI/MWProtScalePeptideMassPeptideCutterExperimental InfoFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsSequence conflicti1D & V in . (PubMed:)Sequence conflicti2LS & GAHQGARLAL in . (PubMed:)Sequence conflicti1S & G in . (PubMed:)Natural variantFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsNatural varianti1 in a lung neuroendocr somatic mutation. "Patterns of somatic mutation in human cancer genomes.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-221 AND HIS-275. VAR_042264Natural varianti1.Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT HIS-275. "Patterns of somatic mutation in human cancer genomes.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-221 AND HIS-275. Corresponds to variant rs [
].VAR_025176Alternative sequenceFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsAlternative sequencei108Missing in isoform . "Complete sequencing and characterization of 21,243 full-length human cDNAs.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). VSP_055221Alternative sequencei118VDIWS&EPEAE & GAGGRPWGDEGQGPRLALDW LCMPGLRGQARSPRMWDPHS KVALQRPLEHDGCWPPLAVQ LWTSPCLGGLGMAEEGVCPS WGLDVTVGLLEEGRGVGTLM EVPSPSHSGYLVRGLHHG in isoform . "Complete sequencing and characterization of 21,243 full-length human cDNAs.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). VSP_055222Alternative sequencei43Missing in isoform . "Complete sequencing and characterization of 21,243 full-length human cDNAs.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). VSP_055223Sequence databases
Select the link destinations:EMBLiGenBankiDDBJi mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . Genomic DNA. Translation: . mRNA. Translation: . mRNA. Translation: . Genomic DNA. Translation: . Genomic DNA. Translation: . Genomic DNA. No translation available. Genomic DNA. Translation: . Genomic DNA. Translation: . Genomic DNA. Translation: . mRNA. Translation: .
UniGeneiHs.57732. Genome annotation databases
Ensembli; ; .
UCSCi human.
[]Polymorphism databases
DMDMi Keywords - Coding sequence diversityi,
Cross-referencesi
Web resourcesi
Sequence databases
Select the link destinations:
mRNA. Translation:
mRNA. Translation:
mRNA. Translation:
mRNA. Translation:
mRNA. Translation:
mRNA. Translation:
mRNA. Translation:
Genomic DNA. Translation:
mRNA. Translation:
mRNA. Translation:
Genomic DNA. Translation:
Genomic DNA. Translation:
Genomic DNA. No translation available.
Genomic DNA. Translation:
Genomic DNA. Translation:
Genomic DNA. Translation:
mRNA. Translation:
3D structure databases
Select the link destinations:
Resolution (&A)
ProteinModelPortali
Protein-protein interaction databases
28 interactions.
21 interactions.
BindingDBi
Regorafenib.
GuidetoPHARMACOLOGYi
PTM databases
PhosphoSitei
Polymorphism databases
Proteomic databases
Protocols and materials databases
Structural Biology Knowledgebase
Genome annotation databases
Organism-specific databases
GeneCardsi
Phylogenomic databases
InParanoidi
PhylomeDBi
Enzyme and pathway databases
p38MAPK events.
ERK/MAPK targets.
Oxidative Stress Induced Senescence.
Activation of PPARGC1A (PGC-1alpha) by phosphorylation.
Activation of the AP-1 family of transcription factors.
activated TAK1 mediates p38 MAPK activation.
CDO in myogenesis.
VEGFA-VEGFR2 Pathway.
KSRP destabilizes mRNA.
DSCAM interactions.
NOD1/2 Signaling Pathway.
SignaLinki
Miscellaneous databases
EvolutionaryTracei
GenomeRNAii
Gene expression databases
ExpressionAtlasi
baseline and differential.
Genevestigatori
Family and domain databases
Kinase-like_dom.
MAP_kinase_CS.
Prot_kinase_dom.
Protein_kinase_ATP_BS.
Ser/Thr_dual-sp_kinase.
Pkinase. 1 hit.
P38MAPKINASE.
S_TKc. 1 hit.
SSF56112. 1 hit.
MAPK. 1 hit.
PROTEIN_KINASE_ATP. 1 hit.
PROTEIN_KINASE_DOM. 1 hit.
Publicationsi"Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta).", , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: . , Submitted (APR-1997) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). "Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles.", , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: . "Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6.", ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION IN PHOSPHORYLATION OF ATF2; ELK1 AND MBP, ENZYME REGULATION. Tissue: . "Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.", , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ENZYME REGULATION. "p38-2, a novel mitogen-activated protein kinase with distinct properties.", , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). "A genome annotation-driven approach to cloning the human ORFeome.", , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). "Complete sequencing and characterization of 21,243 full-length human cDNAs.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: . Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT HIS-275. Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. "The DNA sequence of human chromosome 22.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. , , , , , , , , , , , , , , , , ,
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: . "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.", , ,
[] [] []Cited for: FUNCTION IN ACTIVATION OF RPS6KA5/MSK1. "Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors.", , Mol. Cell. Biol. 19:99)
[] [] []Cited for: FUNCTION IN PHOSPHORYLATION OF MEF2A AND MEF2C. "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs.", , ,
[] [] []Cited for: INTERACTION WITH DUSP16, ENZYME REGULATION. "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.", , ,
[] [] []Cited for: FUNCTION AS MKNK2 KINASE. "Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression.", , , ,
[] [] []Cited for: INTERACTION WITH HDAC3, PHOSPHORYLATION, ENZYME REGULATION, FUNCTION IN ATF2 ACTIVATION. "In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance.",
[] [] []Cited for: REVIEW ON FUNCTION. "Large-scale proteomics analysis of the human kinome.", , , , , , ,
[] [] []Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. "Mechanisms and functions of p38 MAPK signalling.",
[] [] []Cited for: REVIEW ON ENZYME REGULATION, REVIEW ON FUNCTION. "The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha.", , , , , , , , ,
[] [] []Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) IN COMPLEX WITH INHIBITOR. "Patterns of somatic mutation in human cancer genomes.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-221 AND HIS-275. + Q2XNF2Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997Last sequence update: March 20, 2007Last modified: November 26, 2014This is version 161 of the entry and version 2 of the sequence.
[]Entry statusiReviewed (UniProtKB/Swiss-Prot)Annotation programDisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.MiscellaneousiKeywords - Technical termi, , Documents
Human chromosome 22: entries, gene names and cross-references to MIM
List of human entries with polymorphisms or disease mutations
Index of human polymorphisms and disease mutations
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Index of Protein Data Bank (PDB) cross-references
Human and mouse protein kinases: classification and index
Index of protein domains and families
External Data}