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不良信息举报电话:Protein knowledgebaseSequence archiveHelp pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects.Sequence clustersProtein sets from fully sequenced genomesAnnotation systemsSystems used to automatically annotate proteins with high accuracy:Supporting dataSelect one of the options below to target your search:You are using a version of browser that may not display all the features of this website. Please consider upgrading . Collagen alpha-1(XXV) chainCol25a1Mus musculus (Mouse)-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveliFunctioniInhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin (By similarity).Manual assertion inferred from sequence similarity toiGO - Molecular functioniGO - Biological processiInferred from mutant phenotypeiKeywordsiMolecular functionEnzyme and pathway databasesReactomei Collagen degradation.
Collagen biosynthesis and modifying enzymes.
Collagen chain trimerization. Names & TaxonomyiProtein namesiRecommended name:Collagen alpha-1(XXV) chainAlternative name(s):CLAC-PCleaved into the following chain:Short name: CLACGene namesiName:Manual assertion inferred from database entriesiOrganismiTaxonomic identifieri
[]Taxonomic lineagei >
Proteomesi Componenti: Chromosome 3 Organism-specific databasesMGIi Col25a1. Subcellular locationi ;
Note: After proteolytic cleavage, CLAC is secreted.TopologyFeature keyPosition(s)DescriptionActionsGraphical viewLengthTopological domainiCytoplasmic 33TransmembraneiH Signal-anchor for type II membrane protein 21Topological domainiExtracellular 612GO - Cellular componentiInferred from sequence alignmentiInferred from sequence alignmentiKeywords - Cellular componenti, PTM / ProcessingiMolecule processingFeature keyPosition(s)DescriptionActionsGraphical viewLengthChainiPRO_Collagen alpha-1(XXV) chain 666ChainiPRO_Collagen-like Alzheimer amyloid plaque componentManual assertion inferred from sequence similarity toi 542Post-translational modificationiUndergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component.Manual assertion inferred from sequence similarity toiGlycosylated.Manual assertion inferred from sequence similarity toiHydroxylated on proline and lysine residues.Manual assertion inferred from sequence similarity toiSitesFeature keyPosition(s)DescriptionActionsGraphical viewLengthSiteiC by furin2Keywords - PTMi, Proteomic databasesPaxDbi PRIDEi PTM databasesiPTMneti PhosphoSitePlusi ExpressioniTissue specificityiExpressed predominantly in neurons with low levels also detected in heart, testis and eye.Manual assertion based on experiment ini"CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV.", , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.Gene expression databasesBgeei CleanExi ExpressionAtlasi baseline and differential. Genevisiblei MM. InteractioniSubunit structureiForms homodimers and homotrimers. Binds to the fibrillized forms of beta amyloid peptide 40 (beta-APP40) and beta amyloid peptide 42 (beta-APP42). Found associated with beta-APP42 more frequently than with beta-APP40 (By similarity).Manual assertion inferred from sequence similarity toiProtein-protein interaction databasesSTRINGi Structurei3D structure databasesProteinModelPortali ModBaseiMobiDBiFamily & DomainsiDomains and RepeatsFeature keyPosition(s)DescriptionActionsGraphical viewLengthDomainiCollagen-like 1 44DomainiCollagen-like 2 56DomainiCollagen-like 3 60DomainiCollagen-like 4 60DomainiCollagen-like 5 53DomainiCollagen-like 6 60DomainiCollagen-like 7 60DomainiCollagen-like 8 60RegionFeature keyPosition(s)DescriptionActionsGraphical viewLengthRegioniInteraction with beta amyloid peptideManual assertion inferred from sequence similarity toi8Keywords - Domaini, , , , Phylogenomic databaseseggNOGi Eukaryota.
LUCA. GeneTreei HOGENOMi HOVERGENi InParanoidi OMAi OrthoDBi TreeFami Family and domain databasesInterProi CLAC-P.
Collagen. PANTHERi PTHR24023:SF782. 1 hit. Pfami Collagen. 6 hits. SequenceiSequence statusi: Complete.Sequence processingi: The displayed sequence is further processed into a mature form.Q99MQ5-1 []
50MLVKKLAGKG GGRESGSEDP RPLGQRCAGT MPSCTALATL LSVVAVAFCF
100YLGVKTNDLQ ARIAALESAK GTPSFHPLSD TVDELKAMVQ EKVERLLAQK
150SYEHMAKIRT AREAPLECNC PAGPPGKRGK RGRRGESGPP GQPGPQGPPG
200PKGDKGEQGD QGPRMVFPKI NHGFLSADQQ LIKRRLIKGD QGQAGPPGPP
250GPPGPRGPPG DTGKDGPRGM PGVPGEPGKP GEQGLMGPLG PPGQKGSIGA
300PGTPGMDGQK GEPGSPGAAG QSGLPGPKGE PGKEGEKGDA GENGPKGDTG
350EKGDPGSSAA GIKGEPGESG RPGQKGEPGL PGLPGLPGIK GEPGFIGPQG
400EPGLPGLPGT KGDRGEAGPP GRGERGDPGA PGPKGKQGES GARGPKGSKG
450DRGDKGDSGA LGPRGPPGQK GDPGATEIID YNGNLHEALQ RITTLTVTGP
500PGPPGPQGLQ GPKGEQGSPG IPGVDGEQGL KGSKGDMGDP GVPGEKGGLG
550LPGLPGANGV KGEKGDTGLP GPQGPSIIGP PGPPGPHGPP GPMGPHGLPG
600PKGASGLDGK PGSRGADGPI GPHGPAGPKG ERGEKGAMGE PGPRGPYGLP
650GKDGEPGLDG FPGPRGEKGD LGEKGEKGFR GVKGEKGEPG QPGLDGLDAP
660 CQLGPDGLPM PGCWQK
66665,377October 3, 2012 - v2Checksum:iDD8F5CAADE401366BLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutterExperimental InfoFeature keyPosition(s)DescriptionActionsGraphical viewLengthSequence conflictiA → V in
(PubMed:).1Sequence conflictiH → Y in
(PubMed:).1Sequence conflictiA → V in
(PubMed:).1Sequence databasesSelect the link destinations:EMBLiGenBankiDDBJi mRNA. Translation: . Genomic DNA. No translation available. Genomic DNA. No translation available. Genomic DNA. No translation available. Genomic DNA. No translation available. Genomic DNA. Translation: .CCDSi RefSeqi UniGenei Genome annotation databasesEnsembli; ; . GeneIDi KEGGi UCSCi mouse. Cross-referencesiSequence databasesSelect the link destinations:EMBLiGenBankiDDBJi mRNA. Translation: . Genomic DNA. No translation available. Genomic DNA. No translation available. Genomic DNA. No translation available. Genomic DNA. No translation available. Genomic DNA. Translation: .CCDSi RefSeqi UniGenei 3D structure databasesProteinModelPortali ModBaseiMobiDBiProtein-protein interaction databasesSTRINGi PTM databasesiPTMneti PhosphoSitePlusi Proteomic databasesPaxDbi PRIDEi Protocols and materials databasesStructural Biology KnowledgebaseGenome annotation databasesEnsembli; ; . GeneIDi KEGGi UCSCi mouse. Organism-specific databasesCTDi MGIi Col25a1. Phylogenomic databaseseggNOGi Eukaryota.
LUCA. GeneTreei HOGENOMi HOVERGENi InParanoidi OMAi OrthoDBi TreeFami Enzyme and pathway databasesReactomei Collagen degradation.
Collagen biosynthesis and modifying enzymes.
Collagen chain trimerization. Miscellaneous databasesChiTaRSi mouse. PROi SOURCEiGene expression databasesBgeei CleanExi ExpressionAtlasi baseline and differential. Genevisiblei MM. Family and domain databasesInterProi CLAC-P.
Collagen. PANTHERi PTHR24023:SF782. 1 hit. Pfami Collagen. 6 hits. ProtoNetiMiscellaneousiKeywords - Technical termi, Documents
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
Similar proteinsiLinks to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.}