下一步您可以：
我浏览过的机型
最受欢迎品牌
网易公司版权所有您所在位置： &
&nbsp&&nbsp&nbsp&&nbsp
新Poly+A+RNA结合蛋白Kazrin可能参与细胞内mRNA转运和定位.pdf49页
本文档一共被下载：
次 ,您可免费全文在线阅读后下载本文档
文档加载中...广告还剩秒
需要金币：200 &&
你可能关注的文档：
··········
··········
学位论文原创性声明
本人郑重声明：所呈交的论文是我个人在导师指导下独立进行研究工作取
得的研究成果。除了文中特别加以标注引用的内容和致谢的地方外，论文中不包
含任何其他个人或集体己经发表或撰写过的研究成果，与我一同工作的同志对本
研究所做的任何贡献均已在论文中作了明确的说明并表示了谢意。
学位论文作者签名：
学位论文版权使用授权书
本人完全了解天津医科大学有关保留、使用学位论文的规定，即：学校有
权将学位论文的全部或部分内容编入有关数据库进行检索，并采用影印、缩印或
扫描等复制手段保存、汇编以供查阅和借阅。同意学校向国家有关部门或机构送
交论文，并编入有关数据库。
保密 豳，在――￡年解密后适用本授权书。
本论文属于
不保密口。
请在以上方框内打“√”
作者签名：
天津置科大掌硬士掌位论文
mRNA胞内运输和定位是真核基因表达调控的重要一环，依赖细胞骨架特别
是微管系统的主动运输是其中最重要的机制。mRNA如何与马达蛋白 momr
protein 相互作用一直困扰着研究人员，我们已经找到一个能够即结合驱动蛋白
轻链 1dnesinlie；llt
与什么RNA相互作用还不清楚，本研究寻找并确定与蛐相互作用的核酸序
列，探索性研究kazrin在细胞中mRNA转运与定位中的可能作用。
白，与鼠胚和鼠脑总RNA体外结合反应，酚氯仿抽提靶RNA，
正在加载中，请稍后...Development of influenza H7N9 virus like particle (VLP) vaccine: ho...
- PubMed - NCBI
The NCBI web site requires JavaScript to function.
FormatSummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListChoose DestinationFileClipboardCollectionsE-mailOrderMy BibliographyCitation managerFormatSummary (text)Abstract (text)MEDLINEXMLPMID ListCSVCreate File1 selected item: FormatSummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListMeSH and Other DataE-mailSubjectAdditional textE-mailAdd to ClipboardAdd to CollectionsOrder articlesAdd to My BibliographyGenerate a file for use with external citation management software.Create File
2013 Sep 13;31(40):4305-13. doi: 10.1016/j.vaccine.. Epub
2013 Jul 26.Development of influenza H7N9 virus like particle (VLP) vaccine: homologous A/Anhui/1/2013 (H7N9) protection and heterologous A/chicken/Jalisco/CPA1/2012 (H7N3) cross-protection in vaccinated mice challenged with H7N9 virus.1, , , , , , , , , .1Novavax, Inc., 9920 Belward Campus Drive, Rockville, MD 20850, USA. AbstractThe recent emergence of severe human illness caused by avian-origin influenza A(H7N9) viruses in China has precipitated a global effort to rapidly develop and test vaccine candidates. To date, non-A(H7N9) H7 subtype influenza vaccine candidates have been poorly immunogenic and difficulties in production of A(H7N9) virus seed strains have been encountered. A candidate recombinant A(H7N9) vaccine consisting of full length, unmodified hemagglutinin (HA) and neuraminidase (NA) from the A/Anhui/1/2013 and the matrix 1 (M1) protein from the A/Indonesia/05/2005 (H5N1) were cloned into a baculovirus vector. Baculovirus infected Spodoptera frugiperda (Sf9) insect cells secreted virus like particles (VLP) composed of HA, NA, and M1 that resemble mature influenza virions. Genetic construction of vaccine from acquisition of an H7N9 genomic sequence to production of A(H7N9) VLP occurred in 26 days. The immunogenicity and efficacy of A/Anhui/1/2013 (H7N9) VLP vaccine administered on days 0 and 14 were evaluated in a lethal wild-type challenge Balb/c mouse model. Control groups included a non-homologous H7 vaccine (A/chicken/Jalisco/CPA1/2012 (H7N3)-VLP), and A/Indonesia/05/2005 (H5N1)-VLP, or placebo. All vaccines were administered with or without ISCOMATRIX. A(H7N9) VLP elicited hemagglutination-inhibition (HAI) antibody titers of ≥ 1:64 against the homologous virus, cross-reactive HAI against the heterologous A(H7N3), and 3- to 4-fold higher HAI responses in corresponding ISCOMATRIX subgroups. Similarly, all doses of H7N9 VLP elicited anti-neuraminidase (NA) antibody, with 3- to 4-fold higher responses measured in the corresponding ISCOMATRIX subgroups. The non-homologous H7 vaccine induced both H7N3 and H7N9 HAI but no N9 anti-NA antibodies. A lethal murine wild-type A/Anhui/1/2013 (H7N9) challenge demonstrated 100% survival of all animals receiving A(H7N9) and A(H7N3) vaccine, versus 0% survival in A(H5N1) vaccine and placebo groups. Together, the data demonstrate that recombinant H7N9 vaccine can be rapidly developed that was immunogenic and efficacious supporting testing in man as a pandemic influenza H7N9 vaccine candidate.Copyright (C) 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.KEYWORDS: H7N9; H I P V Virus like particlePMID:
[PubMed - indexed for MEDLINE]
Free full textPublication TypesMeSH TermsSubstancesGrant SupportFull Text SourcesOther Literature SourcesMedical
Supplemental Content
External link. Please review our .小柳由纪 cross colors-网络歌手-MV在线观看-高清MV|歌词|MV下载-酷我音乐MV,酷我音乐
&小柳由纪 cross colorsMV
《小柳由纪 cross colorsMV》 - 网络歌手
网络歌手的MV
热门MV推荐
最新MV推荐
本站精彩推荐
K歌作品推荐}